Cosmetic Grade HA

Hyaluronic acid is a high molecular weight polysaccharide with glucuronic acid and N-acetyl-glucosamine as repeating structure unit. HA has strong water retention. Theoretically its binding water capacity is up to 500 ml/g as an ideal natural moisturizing factor.
HA is also an important component of the skin. It can prevent skin from aging and improve the appearance and tactile sensation of skin.
Hyaluronic Acid Gel is an injectable implant indicated for filling deep to very deep wrinkles and/or for volume restoration (cheeks,contours of the face,cheekbones).

Functions and application:

1. Moisturizing
Moisturizing is HA's most important function.Compared to the other moisturizer, the relative humidity of the surrounding has less influence on HA's moisturizing capability. Glycerin, propylene glycol&sorbital, polyethylene glycol, sodium lactic acid etc. are often used as moisturizers in cosmetics. According to special experiment, moisturizers such as glycerin,propylene glycol&sorbital, polyethylene glycol, can absorb moisture from air in high humidity, while in low humidity they absorb moisture rather from the inner skin than from the air, which cause the skin to dry out. Sodium lactic acid, hydroxy sodium pyrrolidone can be used in cosmetics, since they are the components of the cutin layer and can bind water. But the mechanisms of their functions are still not completely clear. Only by considering their capacity to bind water, they are not ideal moisturizers. In low relative humidity (35%), HA also has the highest capacity to absorb moisture. While in higher relative humidity (75%), it has lower absorption of moisture. HA has the capacity to keep good water retention automatically depending on the change of the surrounding humidity.

2. Nourishing HA is a natural intrinsic substance of the skin. Additional out-source HA may act as a supplement to the intrinsic HA of the skin. Because the lower relative molecular weight can penetrate through the surface of the skin and accelerate the nutritional supply of the skin metabolism, so that it can prevent the skin from ageing. It means that HA may function as a cosmetic substance as well as a nutrient. Oral hyaluronic acid supplement acts as an internal cosmetic to hydrate the skin and makes good health care. At present, HA is widely used in cosmetic and health care products in the developed countries such as Japan , USA and Eurpoe.

3. Lubricating and film-building

As a high molecular weight polymer, HA has strong lubricating and film-building properties. The skin-care cosmetics with HA as an ingredient have outstanding lubricating capability. While applied to the skin it can function as a film, make the skin soft, smooth, moist and elastic and protect the skin from external injuries. Hair care products contain HA may form a film layer to keep the hair moist and lubricating. It also may prevent the hair from being electrostatic charged, so that hair can be combed more easily and smoothly.

4. Repairing and preventing skin

Skin scorch or sun burn such as turning skin red, black or decortications and so on caused by sun bathing is mainly due to the ultraviolet sunlight. HA can promote proliferation and division of cuticle cells. It also can capture the free radicals of oxygen. Thus it can accelerate the regeneration of the injured skin or even prevent the skin from being injured. Therefore HA combined with ultraviolet absorbents to be used in sun-proof cosmetics will show synergistic effects. This preparation may decrease the number of ultraviolet damages and heal the injured skin.
Also, Hyaluronan synthases (HAS) play roles in all of the stages of cancer metastasis. By producing anti-adhesive HA, HAS can allow tumor cells to release from the primary tumor mass, and if HA associates with receptors such as CD44, the activation of Rho GTPases can promote epithelial-mesenchymal transition (EMT) of the cancer cells. During the processes of intravasation or extravasation, the interaction of HAS produced HA with receptors such as CD44 or RHAMM promote the cell changes that allow for the cancer cells to infiltrate the vascular or lymphatic systems. While traveling in these systems, HA produced by HAS protects the cancer cell from physical damage. Finally, in the formation of a metastatic lesion, HAS produces HA to allow the cancer cell to interact with native cells at the secondary site and to produce a tumor for itself.